Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle

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Effect of Salvia leriifolia Benth. root extracts on ischemia-reperfusion in rat skeletal muscle

BACKGROUND Salvia leriifolia have been shown to decrease ischemia-reperfusion (I/R) injury in brain tissues. In this study, the effects of S. leriifolia aqueous and ethanolic extracts were evaluated on an animal model of I/R injury in the rat hind limb. METHODS Ischemia was induced using free-flap surgery in skeletal muscle. The aqueous and ethanolic extracts of S. leriifolia (100, 200 and 40...

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Colchicine protects rat skeletal muscle from ischemia/reperfusion injury by suppressing oxidative stress and inflammation

Objective(s): Neutrophils play an important role in ischemia/reperfusion (IR) induced skeletal muscle injury. Microtubules are required for neutrophil activation in response to various stimuli. This study aimed to investigate the effects of colchicine, a microtubule-disrupting agent, on skeletal muscle IR injury in a rat hindlimb ischemia model. Materials and Methods: Twenty-one Sprague-Dawley ...

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Effect of the extract from salvia miltiorrhiza radix (SMR) on skeletal muscle ischemia and reperfusion injury in rabbits

The development of microsurgical techniques for replantation of amputated digits and limbs has led to longer periods of ischemia in the clinical setting. In addition, transplantation of skeletal muscle is employed to treat facial paralysis and Volkmann’s ischemic contracture. To restore function to replanted extremities and transplanted muscle, not only should the ischemic period be shorter tha...

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Antioxidant effect of Legalon(r) SIL in ischemia-reperfusion injury of rat skeletal muscle.

PURPOSE To evaluated the potential antioxidant agent Legalon (r) SIL (silibinin-C-2',3-bis(hydrogensuccinat)) in the skeletal muscle of rats. METHODS IRI was achieved via tourniquet application in Wistar-albino rats. Experimental groups were chosen as (i) sham control, (ii) IRI (3+2 h), (iii) IRI and Legalon (r) SIL-50 (50 mg/kg/i.p.), (iv) IRI and Legalon (r) SIL-100 (100 mg/kg/i.p.), and (v...

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Effects of resveratrol on skeletal muscle in ischemia-reperfusion injury.

BACKGROUND Resveratrol, a polyphenol found in grape and red wine, was previously shown to have free radical scavenging and antioxidant properties in various tissues. In this study, the effects of resveratrol were investigated in muscle tissue concerning the ischemia reperfusion (I/R) injury of rat hindlimb. METHODS Arterial circulation of right hindlimbs of 24 Sprague-Dawley rats was ceased b...

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ژورنال

عنوان ژورنال: BMC Complementary and Alternative Medicine

سال: 2007

ISSN: 1472-6882

DOI: 10.1186/1472-6882-7-23